Established in May 2020, the Materials Science in Extreme Environments University Research Alliance (MSEE URA) is an alliance of 17 research institutions led by Johns Hopkins University working in close collaboration with the Defense Threat Reduction Agency (DTRA). The research is focused on understanding, predicting, and controlling the behavior of materials in extreme conditions caused by weapons of mass destruction. The URA is expected to advance the types of materials that are capable of eliminating stockpiles of chemical and biological weapons while understanding and limiting the damage associated with nuclear blasts.